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Reference interval variation was greater than test result variation for the majority of analytes. Reference sample results differed between laboratories, particularly for ALT and free thyroxine (FT4). As expected, reference interval variation was more substantial in the pediatric population and varied between laboratories using the same instrumentation. Of the seven analytes examined, alanine aminotransferase (ALT), alkaline phosphatase (ALP), and creatinine reference intervals were most variable.

Additionally, 40 clinical laboratories participated in a baseline assessment by measuring six analytes in a reference sample. Data on reference intervals currently used by 37 laboratories were collected through a national survey to examine the variation in reference intervals for seven common laboratory tests. Here, we present data from a national survey conducted by the Canadian Society of Clinical Chemists (CSCC) Reference Interval Harmonization (hRI) Working Group that examines variation in laboratory reference sample measurements, as well as pediatric and adult reference intervals currently used in clinical practice across Canada. Lack of consistency in either sample measurement or reference intervals across laboratories challenges the expectation of standardized patient care regardless of testing location. Numerous studies have shown wide variation in reference intervals, even between laboratories using assays from the same manufacturer.

Reference intervals are widely used decision-making tools in laboratory medicine, serving as health-associated standards to interpret laboratory test results. National Survey of Adult and Pediatric Reference Intervals in Clinical Laboratories across Canada: A Report of the CSCC Working Group on Reference Interval Harmonization.Īdeli, Khosrow Higgins, Victoria Seccombe, David Collier, Christine P Balion, Cynthia M Cembrowski, George Venner, Allison A Shaw, Julie

MPC-BE 1.6.8.5 download the new version for iphone